Cowboys vs 49ers Prediction & Betting Tips for NFL Week 10 on 11/15/2026

The San Francisco 49ers are set to take on the Dallas Cowboys in a Week 10 NFL regular season game. The game will be played at AT&T Stadium in Arlington, Texas, with the retractable roof providing some relief from the moderate rain forecasted. Scheduled for Sunday, November 15, 2026, the game will kick off at 4:25 PM and be broadcast on FOX.

The 49ers come into this game with an impressive 7-1 record under head coach Kyle Shanahan. They have performed strongly both at home and on the road, boasting a 2-1 away record. Their recent win over the Las Vegas Raiders, 38-17, highlights their current form.

On the other side, the Dallas Cowboys, led by head coach Brian Schottenheimer, are striving to improve on their 4-5 season record. Despite a challenging start, they are coming off a close victory against the Indianapolis Colts, 27-23. The Cowboys aim to leverage their home-field advantage to secure another win.

With the 49ers favored by a spread of -4 and a total over/under set at 55.5 points, this game promises to be an intriguing matchup. Both teams will look to capitalize on their strengths, making this a game to watch as the 2026 regular season unfolds.

Cowboys vs 49ers At a Glance (Week 10)

• The San Francisco 49ers hold a 7-1-0 record entering Week 10 of the 2026 regular season.
• The Dallas Cowboys currently have a 4-5-0 record this season.
• The game will be played at AT&T Stadium in Arlington, TX, which features a retractable roof.
• Weather conditions are expected to be cool with a light breeze and moderate rain, though the roof may mitigate its impact.
• The 49ers are favored with a moneyline of -211, while the Cowboys are at +177.
• The point spread for the game is set at 49ers -4 and Cowboys +4.

Dallas Cowboys: Ready for the 49ers Showdown at Home

Offensive Overview

The Dallas Cowboys have been a force on offense this season, ranking 4th in total offensive yards with 3,244 yards. Their passing game is particularly strong, ranking 3rd in the league with 2,312 yards through the air.

Despite the impressive aerial attack, their ground game ranks 18th with 932 rushing yards. The Cowboys are scoring an average of 27.3 points per game, placing them 6th in the league.

Defensive Challenges

The Cowboys' defense has struggled this season, giving up 372.7 yards per game, which ranks 29th in the league. The rushing defense has been a particular area of concern, allowing 147.4 yards per game, ranking 31st.

However, the Cowboys' pass rush has been effective, recording 17 sacks, ranking them 10th. Their ability to generate turnovers is notable, as they have intercepted 4 passes, placing them 9th in that category.

Recent Performance

In their last game, the Cowboys secured a victory against the Indianapolis Colts with a 27-23 win. Dak Prescott was instrumental, throwing for 335 yards and 2 touchdowns without an interception.

Javonte Williams contributed significantly on the ground, rushing for 101 yards and a touchdown. CeeDee Lamb was a standout performer with 195 receiving yards and a touchdown.

Injury Report

The Cowboys are dealing with multiple injuries, with P.J. Locke (S) out due to a concussion and Jake Ferguson (TE) sidelined with a knee injury. Other key players like Tyler Goodson (RB) and KaVontae Turpin (WR) are also questionable for the upcoming game.

George Pickens (WR) is dealing with a hamstring injury and is questionable for Week 10. These injuries could impact their offensive dynamics against the 49ers.

Key Betting Trends

• The Cowboys have hit the over in all 4 recent games as underdogs.
• They are 11-3-1 on the over in their last 15 regular-season games.
• At home, they are 6-1 on the over in their last 7 games.
• After a win, the Cowboys have gone over in 4 of their last 5 games.
• They have won 4 of their last 5 games following a loss.

San Francisco 49ers Look to Continue Their Strong Season Against the Dallas Cowboys

Offensive Firepower

The San Francisco 49ers have been one of the top offensive teams in the 2026 NFL season. They are averaging 29.4 points per game, ranking 3rd in the league. Their ability to gain 376.8 offensive yards per game also places them 5th overall.

Quarterback Brock Purdy has been instrumental in this success, throwing for 1980 yards and 17 touchdowns. Running back Christian McCaffrey has also contributed significantly, with 457 rushing yards and nine rushing touchdowns.

Defensive Dominance

On the defensive side, the 49ers have been nearly as impressive. They are allowing just 19.5 points per game, ranking 5th in the NFL. Their defense is especially strong against the rush, allowing only 80.9 rushing yards per game, which is 2nd best in the league.

Players like linebacker Fred Warner and defensive end Nick Bosa have been key contributors. Warner's leadership and tackling ability, along with Bosa's pass-rushing prowess, have been vital to the team's defensive success.

Key Players to Watch

With a strong offensive lineup, the 49ers have several key players to keep an eye on. Besides Purdy and McCaffrey, tight end George Kittle remains a crucial target, with 483 receiving yards and five touchdowns. Wide receiver Mike Evans, despite being questionable with an injury, has been a top target with 420 receiving yards and three touchdowns.

On defense, Fred Warner is a standout player, leading the team in tackles. Nick Bosa, with his ability to pressure opposing quarterbacks, will also be a crucial player to watch against the Cowboys.

Injury Concerns

The 49ers have a few injury concerns heading into their game against the Cowboys. Mike Evans and Deebo Samuel Sr. are both listed as questionable. These two receivers are integral to the 49ers' passing game, and their availability could impact the team's offensive strategy.

On defense, cornerback Renardo Green is also questionable. His potential absence could challenge the secondary's depth against the Cowboys' passing attack.

Betting Trends

• The 49ers have won 11 of their last 12 games as favorites.
• They have a 13-2 record in their last 15 regular season games.
• On the road, the 49ers have a 5-1 record in their last 6 games.
• Against the spread, they are 11-4 in their last 15 regular season games.
• As favorites, they are 9-3 against the spread in their last 12 games.

Cowboys vs 49ers Prediction: 49ers -4

The San Francisco 49ers come into this game with an impressive 7-1 record, showcasing strong performance on both sides of the ball. Their offense ranks 3rd in points per game with 29.4, and their defense is equally formidable, allowing only 19.5 points per game. The 49ers have consistently covered the spread in recent games against the Cowboys, making them a reliable pick.

On the other hand, the Dallas Cowboys have struggled this season, especially at home with a 1-3 record. Despite their high-scoring offense, which ranks 6th in the league, their defense has been porous, allowing 26.2 points per game. This weakness may be exploited by the 49ers' balanced attack.

Given the 49ers' recent success against the Cowboys and the current spread of 4 points, betting on the 49ers to cover seems prudent. Their superior defensive capabilities and offensive efficiency provide them with a strong advantage in this matchup.

Projected final score: 49ers 31, Cowboys 24. The 49ers' ability to control the game on both ends of the field should see them win and cover the spread comfortably.

• Cowboys vs 49ers Prediction: 49ers -4
• Cowboys vs 49ers Score: 49ers 31 - Cowboys 24

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