Cardinals vs Seahawks Prediction & Betting Tips for NFL Week 2 on 9/20/2026

The Week 2 NFL matchup between the Seattle Seahawks and the Arizona Cardinals is set to take place at State Farm Stadium in Glendale, Arizona. Both teams are coming off victories in their opening games, setting the stage for an exciting NFC West divisional encounter. The game will kick off at 4:25 PM on Sunday, September 20, 2026, and will be televised on FOX.

Under the guidance of head coach Mike Macdonald, the Seattle Seahawks started their season with a narrow 13-10 victory over the New England Patriots. The Seahawks showcased a strong defensive performance, recording three interceptions and holding the Patriots to only 10 points. Key players like Jaxon Smith-Njigba and Drew Lock led the offensive charge with notable contributions.

On the other hand, the Arizona Cardinals, coached by Mike LaFleur, dominated the Los Angeles Chargers with a 26-14 win in Week 1. Jacoby Brissett's impressive 277 passing yards and the Cardinals' balanced offensive attack were crucial in their road victory. Their defense also performed admirably, forcing turnovers and limiting the Chargers' scoring opportunities.

The consensus odds favor the Seahawks with a moneyline of -209 and a spread of -4.5, while the Cardinals are set at +174 and +4.5, respectively. With both teams looking to maintain their perfect start to the season, this game promises to be a compelling showdown in the NFC West.

Cardinals vs Seahawks At a Glance (Week 2)

• The Seattle Seahawks have a 1-0-0 record entering Week 2 of the 2026 regular season.
• The Arizona Cardinals also hold a 1-0-0 record as they head into their second game.
• State Farm Stadium in Glendale, AZ, featuring a retractable roof, will host the game.
• The game will take place on Sunday, September 20, 2026, at 4:25 PM.
• On the moneyline, the Seahawks are favored with odds of -209, while the Cardinals are at +174.
• The point spread has the Seahawks at -4.5 and the Cardinals at +4.5.

Arizona Cardinals Set to Battle Seahawks at Home

Offensive Performance

The Arizona Cardinals have kicked off the 2026 season with a strong offensive performance, averaging 26 points per game, which ranks 12th in the league. They are currently 8th in total offensive yards, managing 393 yards per game. Their passing game is particularly strong, ranking 5th with 277 passing yards per game.

The rushing attack, while not as dominant, is still effective, ranking 15th with 116 yards per game. The Cardinals have been efficient in moving the chains, securing 23 first downs per game, ranking them 4th. Their third-down conversion rate stands at 42.9%, placing them 12th in the league.

Defensive Strengths

Defensively, the Cardinals have been formidable, allowing just 14 points per game, the 4th best in the NFL. They rank 9th in total defense, giving up only 268 yards per game. Their ability to stop the run has been impressive, holding opponents to just 81 rushing yards per game, 7th best in the league.

Arizona's pass defense ranks 13th, limiting opponents to 187 passing yards per game. The defensive front has generated pressure, recording 3 sacks, ranking 3rd. The Cardinals have also been opportunistic, with 1 interception and 1 fumble recovery, both ranking 3rd.

Key Players to Watch

Jacoby Brissett leads the offense at quarterback, with 277 passing yards and 1 touchdown in the opening game. Tight end Trey McBride has emerged as a reliable target, contributing 95 receiving yards and a touchdown. On the ground, Tyler Allgeier leads with 61 rushing yards.

On defense, safety Andrew Wingard has made significant contributions with an interception. Defensive tackle Dante Stills has added a sack to his name. Budda Baker continues to be a cornerstone of the defense with multiple tackles and half a sack in their last game.

Injury Concerns

The Cardinals are dealing with several injuries, particularly at the running back position with James Conner on injured reserve. Trey Benson is also out for the season, impacting their depth. Additional concerns include Garrett Williams, who is questionable with an Achilles issue.

On the offensive line, Isaiah Adams is questionable due to a knee injury, which could affect their pass protection. The defense will miss Joey Blount, who is out for the season with a neck injury. These injuries could impact their upcoming performance against the Seahawks.

Team Betting Trends

• In their last 6 home games, the Cardinals have a 5-1 record against the total points line.
• Across the last 14 games overall, they have a 9-5 record against the total points line.
• When listed as underdogs in the past 13 games, they have a 61.5% success rate against the total points line.
• In away games, they have a 50% success rate against the total points line over the past 8 games.
• However, they have struggled against the spread in home games, going 1-4 in their last 5.

Seattle Seahawks Ready to Soar Against the Cardinals

Team Overview

The Seattle Seahawks enter Week 2 of the 2026 NFL Regular Season with a 1-0 record after a narrow victory over the New England Patriots, 13-10. The team is set to face the Arizona Cardinals at State Farm Stadium. Seattle’s offense and defense both showed promising signs in their opening game.

With their win over the Patriots, the Seahawks showcased their defensive capabilities, holding New England to just 10 points. Seattle's defense ranks 2nd in the league for points allowed per game, showing its strength early in the season.

Key Players to Watch

Quarterback Drew Lock leads the Seattle offense, coming off a game with 187 passing yards and one touchdown. His connection with wide receiver Jaxon Smith-Njigba will be crucial, as Smith-Njigba had an impressive performance with 8 receptions, 122 yards, and a touchdown in Week 1.

On the ground, running back Jadarian Price will look to improve upon his 52 rushing yards against the Patriots. The Seahawks' balanced offensive attack will aim to capitalize against a Cardinals team eager to find its footing.

Injury Report and Impact

The Seahawks have several players dealing with injuries, including Sam Darnold, who is questionable with a hip issue. Zach Charbonnet and Irv Charles are among those on injured reserve, impacting the team's depth.

Ty Okada and Tory Horton are also listed as questionable, which may affect Seattle's defensive and special teams units. The Seahawks will need to rely on their depth to fill these gaps effectively.

Betting Trends

• The Seahawks are 12-0 in their last 12 games as favorites.
• Seattle is undefeated in its last 8 regular season games.
• They have a 4-0 record in their last 4 away games.
• Against the spread, the Seahawks are 7-1 in their last 8 away games.
• They are 8-3 against the spread after a win in their last 11 games.

Cardinals vs Seahawks Prediction: Over 41.0

The upcoming game between the Seattle Seahawks and the Arizona Cardinals presents an intriguing opportunity for a high-scoring affair. The Cardinals have demonstrated offensive strength with a scoring average of 26 points per game this season, while the Seahawks are capable of matching that with their explosive offensive potential. This makes the 41.0 total points line appear achievable.

Arizona's recent betting trends also suggest a leaning towards the over in their games, particularly when playing at home. Their record of 5-1 in hitting the over in their last six home games supports the potential for this game to surpass the set total. Additionally, the Cardinals have managed to hit the over in 64.3% of their last 14 regular-season games.

The Seahawks' defense, though ranked second in points allowed, might face challenges containing the Cardinals’ top 5 passing attack. Furthermore, the history between these two teams often results in games that go beyond the total, evidenced by past matchups like the 44-22 game in November 2025. Given these factors, backing the over seems a prudent choice.

Considering the offensive capabilities and historical data, a projected final score of Arizona Cardinals 27 - Seattle Seahawks 24 indicates a game that comfortably surpasses the 41.0 point threshold. This supports the decision to pick the over for this matchup.

• Cardinals vs Seahawks Prediction: Over 41.0
• Cardinals vs Seahawks Score: Cardinals 27 - Seahawks 24

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