Vanderbilt vs Ole Miss Prediction & Betting Tips for Week 6 on 10/10/2026

This Week 6 matchup features the Ole Miss Rebels traveling to FirstBank Stadium to take on the Vanderbilt Commodores. Ole Miss, ranked #9 in the AP Poll, holds a 3-1 record for the season, with their only loss occurring on the road. The game will be broadcasted on ESPN at 3:30 PM ET, offering a key Southeastern Conference matchup on the afternoon slate.

Vanderbilt, with a 3-2 record, looks to maintain their unbeaten streak at home. The Commodores have struggled in conference play with a 0-2 record, dropping their previous two games on the road. Their performance at FirstBank Stadium has been strong, and they'll aim to utilize this home advantage.

Ole Miss enters this contest with a notable passing game, having recorded 298 passing yards in their previous road game against Florida. They face a Vanderbilt team that has shown resilience at home, evidenced by their close win against North Carolina State. Both teams will be looking to assert their dominance within the conference standings.

Vanderbilt vs Ole Miss At a Glance (Week 6)

• Game Venue: FirstBank Stadium in Nashville, TN
• Game Date & Time: Saturday, October 10, 2026 at 3:30 PM ET
• TV Broadcast: ESPN
• Ole Miss Record: 3-1 overall, 0-1 on the road
• Vanderbilt Record: 3-2 overall, 3-0 at home
• Odds: Ole Miss favored with a -9.5 spread, total points set at 59.0

Vanderbilt Commodores Prepare for Home Game Challenge

Current Offensive Performance

The Vanderbilt Commodores have accumulated 127 points so far this season, placing them 53rd in scoring across the nation. Their passing game, led by Jared Curtis and Blaze Berlowitz, has contributed significantly with 1,132 yards, ranking 65th. However, the rushing attack has been less effective, totaling 621 yards and ranking 96th.

First downs have been a bright spot for the Commodores, with 92 recorded, positioning them 41st nationally. This reflects their ability to sustain drives, a crucial aspect when facing tough opponents. The team will need to improve their rushing game to support their passing efforts and maintain their offensive momentum.

Defensive Highlights

Defensively, Vanderbilt has allowed 125 points, placing them 81st in the country. Despite this, the team has excelled in creating pressure, registering 14 sacks which ranks them 8th nationally. This pass-rush ability could be a key factor in their upcoming games.

Interceptions and fumble recoveries have also been strengths, with 4 interceptions (5th) and 2 fumble recoveries (7th). These turnover opportunities will be essential for the Commodores to stay competitive and turn the tide in tight games.

Key Players to Watch

Jared Curtis has been the mainstay at quarterback, throwing for 746 yards and 4 touchdowns in 4 games. His backup, Blaze Berlowitz, has added 368 yards and 1 touchdown. Both quarterbacks have shown resilience and ability to execute the game plan effectively.

In the backfield, Sedrick Alexander has been the leading rusher with 200 yards and 4 touchdowns. Makhilyn Young complements him with 134 yards and 1 touchdown, while Junior Sherrill leads the receiving corps with 474 yards and 3 touchdowns.

Injury Concerns

The Commodores will have to navigate injury challenges, particularly with Jared Curtis listed as questionable. Aaron Bryant is out for the season with a torn ACL, which could impact their defensive line depth. The status of Jaylin Lackey and Jamison Curtis remains uncertain as they deal with undisclosed injuries.

Upcoming Game Overview

Vanderbilt's next challenge is a home game against the Ole Miss Rebels at FirstBank Stadium. This matchup is crucial as the Commodores aim to rebound from a recent 38-14 loss to Georgia. Their defensive line's ability to pressure the quarterback and force turnovers will be pivotal against the Rebels.

Betting Trends

• SU - As Favorite: 11-0 in the last 11 games
• SU - Home Games: 10-0 in the last 10 games
• ATS - Away Games: 10-1 in the last 11 games
• ATS - After Loss: 10-1 in the last 11 games
• ATS - As Underdog: 14-3 in the last 17 games
• O/U - As Favorite: 15-4 in the last 19 games
• ATS - All Games: 22-8 in the last 30 games

Ole Miss Rebels Seek Redemption on the Road

Quarterback Leadership

Trinidad Chambliss is expected to lead the Ole Miss offense as the starting quarterback. With 1,222 passing yards this season, Chambliss ranks 30th nationally, displaying his ability to move the ball through the air. His performance will be pivotal in setting the tone for the Rebels' offense.

Chambliss has thrown eight touchdowns this season, though interceptions have been a concern with three already. Improving his accuracy and minimizing turnovers will be essential against Vanderbilt. His leadership and decision-making will be under scrutiny as Ole Miss looks to bounce back from their recent defeat.

Rushing Attack and Injuries

Running back Kewan Lacy, who is dealing with a shoulder injury, remains crucial to the Rebels' ground game. Lacy has accumulated 191 rushing yards and scored four touchdowns in three games. His ability to contribute despite injury concerns will be crucial for the Rebels' offensive balance.

Backup options like JT Lindsey and Makhi Frazier offer depth in the backfield, combining for 159 rushing yards. However, they have yet to find the end zone this season. Establishing the run will be key to opening up the passing game against Vanderbilt.

Wide Receiver Depth

Deuce Alexander has emerged as the leading receiver for Ole Miss with 429 receiving yards and four touchdowns. His performance will be vital for Trinidad Chambliss in stretching the field. Alexander's ability to find separation and make plays will be closely watched in this matchup.

Traylon Ray and Horatio Fields offer additional targets, combining for 26 receptions and two touchdowns. Their contributions are essential for keeping the defense honest and creating opportunities for the Rebels' offense. The receiving corps' performance will be a factor in Ole Miss' offensive success.

Defensive Challenges

Ole Miss' defense has struggled this season, allowing 123 points, ranking 79th nationally. Improving on this front is crucial for their success against Vanderbilt. The defensive line has shown potential with six sacks, ranking 16th, but consistency is needed across the board.

In the secondary, the Rebels have two interceptions, ranking 3rd nationally, showcasing their ability to capitalize on mistakes. However, with several key players dealing with injuries, depth and resilience will be tested. The defense must step up to provide the offense with more opportunities.

Team Betting Trends

• SU - Home Games: Last 25 Games (2023–2026) → 24-1 (96.0%)
• SU - As Favorite: Last 30 Games (2023–2026) → 27-3 (90.0%)
• SU - After Loss: Last 7 Games (2023–2025) → 7-0 (100.0%)
• O/U - Away Games: Last 5 Games (2025–2026) → 4-1 (80.0%)
• SU - Away Games: Last 21 Games (2021–2026) → 13-8 (61.9%)

Vanderbilt vs Ole Miss Week 6 Prediction: Vanderbilt +9.5

As we look towards the Week 6 matchup between Ole Miss and Vanderbilt, the Rebels find themselves as 9.5-point favorites. Ole Miss comes into this game ranked #9 in the AP poll, with a season record of 3-1. However, it's worth noting that they have yet to win a game on the road this season, having lost their only away game so far.

On the other hand, Vanderbilt, with a 3-2 record, has displayed a strong home performance, being undefeated at FirstBank Stadium this season. Historically, Vanderbilt has been successful against the spread (ATS) as underdogs, covering the spread in 82.4% of their last 17 games in this scenario. This trend suggests they are well-positioned to cover the spread in their upcoming game against Ole Miss.

The betting odds show Ole Miss as the consensus favorite with a moneyline of -352, while Vanderbilt's moneyline is set at +279. However, given Vanderbilt's strong home record and their ability to cover the spread, the better value appears to be on Vanderbilt to cover the +9.5 spread.

While Ole Miss has a potent offense, Vanderbilt's consistent play at home and their impressive ATS record as underdogs suggest a competitive game. A projected final score of Ole Miss 31 - Vanderbilt 24 supports the prediction of Vanderbilt covering the spread.

• Vanderbilt vs Ole Miss Prediction: Vanderbilt +9.5
• Vanderbilt vs Ole Miss Score: Ole Miss 31 - Vanderbilt 24

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